Definition: An artificial microscopic vesicle consisting of an aqueous core enclosed in one or more phospholipids layers, used to convey vaccines, drugs, enzymes, or other substances to target cells or organs. Introduction ¡ Liposome was found by Alec Bingham of Babraham Institute in Cambridge, England in 1965. ¡ In 1990, drugs with liposome and Amphotericin B were approved by Ireland. ¡ In 1995 America F.D.A approved liposor doxodubicin. ¡ Liposome is a lipid vesicle suspending in the hydro-phase with a diameter around 0.0025~3.5um. The membrane of liposome is made of phospholipids, which have phosphoric acid sides to form the liposome bilayers. Composition of liposomes: A. Phospholipids The most common natural phospholipid is the phospatidylcholine (PC) is the amphipathic molecule and also known as lecithin. Naturally occurring phospholipids used in l...
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