e-Pharmatimes

Introduction: Recent developments in the pharmaceutical technology have presented viable dosage alternatives from oral route for pediatrics, geriatric, bedridden, nauseous or noncompliant patients. Among these the use of oral thin films for buccal delivery, also known as mouth dissolving film is gaining much attention. A new drug delivery system for the oral delivery of the drugs, was developed based on the technology of the transdermal patch. The delivery system consists of a very thin oral strip, which is placed on the patient’s tongue or any oral mucosal tissue, which instantly gets wet by saliva and the film gets rapidly hydrated and adheres onto the site of application. It then rapidly disintegrates and dissolves to release the medication. OTFs offer fast, accurate dosing in a safe, efficacious format that is convenient and portable, without the need for water. OTFs are typically the size of a postage stamp and disintegrate on a patient's tongue in a matter of seconds f...